Web14 de set. de 2024 · Multiple mechanisms have been proposed to explain radiation-induced effects on normal brain tissue at a cellular level. 1 The primary mechanism that has been proposed is the ischemia-hypoxia cascade induced by RT leading to increased glutamate levels which, in turn, lead to excessive activation of N-methyl-D-aspartate (NMDA) … WebLong-term cognitive impairments are a feared consequence of therapeutic cranial irradiation in children as well as adults. Studies in animal models suggest that these deficits may be …
Treatment of Radiation-Induced Brain Necrosis - PubMed
Web13 de out. de 2024 · Radiation therapy damages the DNA of cancer cells to help shrink tumors or slow the progression of cancer. It can also damage healthy cells and lead to … WebCranial radiation therapy and damage to hippocampal neurogenesis Dev Disabil Res Rev. 2008;14(3):238-42. doi: 10.1002/ddrr.26. Author Michelle Monje 1 Affiliation 1 … 7画 漢字 王
Memantine for Prevention of Brain Irradiation–Induced Cognitive ...
Ionizing radiation is classified as a neurotoxicant. A 2004 cohort study concluded that irradiation of the brain with dose levels overlapping those imparted by computed tomography can, in at least some instances, adversely affect intellectual development. Radiation therapy at doses around "23.4 Gy" was found to cause cognitive decline that was especially apparent in young children who underwent the treatment for cranial tumors, between … Web20 de mai. de 2013 · 10009 Background: Radiation therapy (RT), an essential treatment for pediatric brain tumors, increases the risk of cognitive impairment. Advanced RT techniques reduce the volume of normal tissues receiving radiation dose. Proton beam radiation therapy (PBRT) minimizes irradiation to surrounding healthy brain tissue, with the … WebTherefore, those who are younger at the time of radiation treatment generally have less or fully developed white matter. Since both younger and older patients have shown to lose white matter volume at similar rates, the younger irradiated patients continue to display reduced total white matter volume following radiation treatment. 7画 漢字