WebIn addition, we investigated the effects of farnesoid X receptor agonist GW4064 on hepatic ApoM expression in vitro. In HepG2 cell cultures, both mRNA and protein levels of ApoM and LRH-1 were decreased in a time-dependent manner in the presence of 1 µM GW4064, and the inhibition effect was gradually attenuated after 24 hours. Farnesoid X receptor has been shown to interact with: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha and; Retinoid X receptor alpha. Ligands. A number of ligands for FXR are known, of both natural and synthetic origin. Agonists. Cafestol; Chenodeoxycholic acid; Fexaramine; GW … See more The bile acid receptor (BAR), also known as farnesoid X receptor (FXR) or NR1H4 (nuclear receptor subfamily 1, group H, member 4), is a nuclear receptor that is encoded by the NR1H4 gene in humans. See more FXR is expressed at high levels in the liver and intestine. Chenodeoxycholic acid and other bile acids are natural ligands for FXR. Similar to other nuclear receptors, when activated, FXR … See more A number of ligands for FXR are known, of both natural and synthetic origin. Agonists • Cafestol • Chenodeoxycholic acid See more • "Farnesoid X Receptor (NR1H4)". Nuclear Receptor Resource. Archived from the original on 2015-01-12. Retrieved 2015-01-12. • farnesoid+X-activated+receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more Farnesoid X receptor has been shown to interact with: • Peroxisome proliferator-activated receptor gamma coactivator 1-alpha and • Retinoid X receptor alpha See more • Kalaany NY, Mangelsdorf DJ (2006). "LXRS and FXR: the yin and yang of cholesterol and fat metabolism". Annual Review of Physiology. 68: 159–91. doi: • Kuipers F, Stroeve … See more

The role of the farnesoid X receptor in kidney health and disease: …

WebThe farnesoid X receptor (FXR) is a nuclear receptor that plays key roles in hepatoprotection by maintaining the homeostasis of liver metabolism. FXR null mice display strong hepatic … WebThe Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily and has emerged as a key player in the control of multiple metabolic pathways. On its activation … office-friendly bike clothing

Farnesoid x receptor agonists: what they are and how they ... - PubMed

WebFeb 3, 2024 · The farnesoid X receptor (FXR, NR1H4) is a primary nuclear bile acid receptor that transcriptionally regulates bile acid homeostasis as well as glucose and lipid metabolism in multiple tissues. The roles of FXR in tissues other than hepatic and intestinal tissues are poorly understood. WebAug 1, 2024 · Farnesoid X receptor (FXR) is a transcription factor that can be activated by bile acid as well as influenced bile acid metabolism. β-cell bile acid metabolism is mediated by FXR and closely related to the regulation of blood glucose (BG). FXR can regulate BG through multiple pathways. WebOct 31, 2024 · The Farnesoid-X Receptor, FXR, is a nuclear bile acid receptor. Its originally described function is in bile acid synthesis and regulation within the liver. More recently, however, FXR has been increasingly appreciated for its breadth of function and expression across multiple organ systems, including the intestine. mycloud not on network